The research team led by Claudia Gundacker, Associate Professor at the Institute of Medical Genetics, has discovered a previously unknown mechanism in preeclampsia, which is a serious pregnancy complication.
First authors Sebastian Granitzer and Raimund Widhalm (Institute of Medical Genetics, MedUni Vienna) and co-authors show that the amino acid transporter LAT1 and the transcription factor NRF2 interact to regulate the sFlt-1/PlGF ratio and control oxidative stress in the placenta. The results provide new insights into the molecular causes of preeclampsia. The study was supported by Gesellschaft für Forschungsförderung Niederösterreich (GFF NÖ).
Publication:
Granitzer, S., Widhalm, R., et al. (2025). LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia. Nature Communications