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Chiba Lab

Peter Chiba, Ao. Univ.-Prof. Dr.

Medical Specialist

Tel.: +43 (0)1 40160-38005

ABC transporters as targets for pharmacologically active small molecules

ATP Binding Casette (ABC) transporters are found in all living organisms. They are capable of moving cargo across biological membranes in an energy dependent and vectorial manner. Human ABC transporters mediate efflux of diverse solutes including drugs and drug conjugates, peptides, ions and endogenous organic molecules such as bile salts and uric acid. Malfunction of ABC-transporters leads to hereditary and acquired diseases such as cystic fibrosis, intrahepatic cholestasis and gout. Multispecific ABC transporters play an important role in drug disposition and drug-drug interactions. Our group is interested in developing a functional understanding of the interaction of small molecules with ABCB subfamily transporters and to use this knowledge in making ABCB transporter related diseases amenable to therapeutic intervention.