ABC transporters as targets for pharmacologically active small molecules
ATP Binding Casette (ABC) transporters are found in all living organisms. They are capable of moving cargo across biological membranes in an energy dependent and vectorial manner. Human ABC transporters mediate efflux of diverse solutes including drugs and drug conjugates, peptides, ions and endogenous organic molecules such as bile salts and uric acid. Malfunction of ABC-transporters leads to hereditary and acquired diseases such as cystic fibrosis, intrahepatic cholestasis and gout. Multispecific ABC transporters play an important role in drug disposition and drug-drug interactions. Our group is interested in developing a functional understanding of the interaction of small molecules with ABCB subfamily transporters and to use this knowledge in making ABCB transporter related diseases amenable to therapeutic intervention.
Novel compounds with antimalarial activity - ex vivo characterization in clinical isolates und elucidation of the mechanism of action
Malaria is one of the most prevalent tropical diseases with half of the world's population being at risk for contracting the disease. Though initiatives to curb malaria have gained a global momentum, rapid development of parasite resistance to standard regimens is a major concern. Identification of novel chemical starting points for developmental compounds and identification of their molecular targets are central to our research effort.