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Mikula Lab

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Mario Mikula, Assoc. Prof. Priv. Doz. Mag. Dr., MAS

Genetiker und Toxikologe

Tel: + 43 (0)1 40160-56540
E-Mail: mario.mikula@meduniwien.ac.at

Research Focus

Differentiation programs active during melanoma development

Starting from embryonic stem cells, developmental programs lead to the formation of all organs in the human body. This implies that cellular differentiation mechanisms are powerful determinators of cellular fate. The reactivation of these conserved developmental programs, like EMT (Epithelial Mesenchymal Transition), during and after pathologic events, has profound impact on the outcome of disease. Focussing on cancer, de-differentiation along with tumor progression can be observed. In particular our research has shown that melanoma cells loose differentiation and at the same time gain cancer specific characteristics.

Funded Projekts

We have been or are funded by the following agencies:

  • Herzfeldersche Familienstiftung: Role of FGF signaling in Melanoma
  • Austrian National Bank: Reactivation of Embryonic Pathways in Melanoma
  • Austrian Science Fund FWF (P32979-B): Identification of a novel HIF regulation in human melanoma.
  • Austrian Science Fund FWF (P 25336-B13): The Lipogenic Phenotype in Melanoma
  • Austrian Science Fund FWF (P32979-B): Identification of a novel HIF regulation in human melanoma. 
  • Austrian Science Fund FWF (P 25336-B13): The Lipogenic Phenotype in Melanoma

  • Austrian Research Promotion Agency (FFG 841291): Generation of a Metastasis Specific Antibody.

  • NFB (LS18-014): Isolation and therapeutic use of extracellular vesicles derived from stem cells

  • NFB (LS14-007): NRF2 in Melanoma 

  • NFB (LS11-07): Chondrogenic Differentiation of Stem Cells

Unser Team

Oliver Eckel (PhD student), Laurenz Vock (PhD student), Madalina Mirea (Research Assistent), Anna Gschwendtner (PhD student)
Oliver Eckel (PhD student), Laurenz Vock (PhD student), Madalina Mirea (Research Assistent), Anna Gschwendtner (PhD student)

Alumni

Birgit Schütz, Ph.D. (Melanoma Macrophage interaction), Martina Pistek, B.Sc. (Cholesterol synthesis in melanoma), Robert Soukup, M.Sc. (Stat3 in melanoma), Stefan Eckensperger (Stem cell differentiation), Hans Peter Weitzenböck, Ph.D. (NRF2 in melanoma)
Katharina Kinslechner, Ph.D. (Role of SR-BI in melanoma), Maria Vallianou, M.Sc. (Tumor organoids), David Schörghofer, Ph.D. (Melanoma differentiation), Ing. Jelena Brankovic (Technical support), Andrea Preitschopf, Ph.D. (Stem cell differentiation), Kerstin Müller, M.Sc. (Effect of anti melanoma antibodies), Philipp Rapolter, M.Sc. (SR-BI in vesicle secretion), Christoph Lammel, M.Sc. (ROS generation in melanoma), Mohammed Helal Uddin, M.Sc. (Chondrogenic differentiation), Alexander Swoboda, Ph.D. (Patient-derived cell lines)