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Aged blood vessels deteriorate bone

A research team led by Osmanagic-Myers from the Center of Pathobiochemistry & Genetics has demonstrated for the first time in an in vivo context, that aged blood vessels secrete microRNA-mediated signals perturbing bone homeostasis.

This leads to cortical bone thinning that significantly contributes to bone loss in elderly. In particular, paracrine senescence-associated microRNA-31-5p signals derived from the aged vascular niche are shown to inhibit pro-osteogenic Wnt-signaling in bone marrow mesenchymal stem cells. Findings from this study are expected to provide insight into the vascular-bone crosstalk and shed light on the concurrent development of vascular and bone diseases in the elderly population. Furthermore, targeting microRNA-31-5p may represent a promising strategy to combat bone loss in the elderly. This study was recently published in the journal “Aging Cell”.

For more details on the work check the link

Please check also our recent review on “premature aging” DOI: 10.3389/fragi.2023.1327833