This leads to cortical bone thinning that significantly contributes to bone loss in elderly. In particular, paracrine senescence-associated microRNA-31-5p signals derived from the aged vascular niche are shown to inhibit pro-osteogenic Wnt-signaling in bone marrow mesenchymal stem cells. Findings from this study are expected to provide insight into the vascular-bone crosstalk and shed light on the concurrent development of vascular and bone diseases in the elderly population. Furthermore, targeting microRNA-31-5p may represent a promising strategy to combat bone loss in the elderly. This study was recently published in the journal “Aging Cell”.
For more details on the work check the link https://doi.org/10.1111/acel.14139
Please check also our recent review on “premature aging” DOI: 10.3389/fragi.2023.1327833